top of page

Publications

Google Scholar

Research articles (Selective)

  • ​Pan Y, Hysinger JD, Barron T, Schindler NF, Cobb O, Guo X, Yalçın B, Anastasaki C, Mulinyawe SB, Ponnuswami A, Scheaffer S, Ma Y, Chang KC, Xia X, Toonen JA, Lennon JJ, Gibson EM, Huguenard J, Liau LM, Goldberg JL, Monje M*# and Gutmann DH*# “NF1 mutation drives neuronal activity-dependent optic glioma initiation” Nature. 2021, 594(7862):277-282.

  • Luo Z#, Chang KC#, Wu S, Sun C, Xia X, Nahmou M, Bian M, Wen RR, Zhu Y, Shah S, Tanasa B, Wernig M, Goldberg JL* "Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo" Stem cell reports, 2022, 17(12):2690-2703 (#Co-first author).

  • Huang YK, Liu CC, Cheng HC, Meadows C and Chang KC* “The influence of aldose reductase in beta-amyloid induced microglia activation" Int J Mol Sci. 2022, 23(23):15088.

  • Rao M, Huang YK, Liu CC, Meadows C, Cheng HC, Zhou M, Chen YC, Xia X, Goldberg JL, Williams AM, Kuwajima T and Chang KC* “Aldose reductase inhibition decelerates optic nerve degeneration by suppressing retinal microglia activation" Scientific Reports. 2023, 13(1):5592.

  • Cameron EG, Nahmou M, Toth AB, Heo L, Tanasa B, Dalal R, Yan W, Nallagatla P, Xia X, Hay S, Knasel C, Stiles TL, Douglas C, Atkins M, Sun C, Ashouri M, Bian M, Chang KC, Russano K, Shah S, Woodworth MB, Galvao J, Nair RV, Kapiloff MS, Goldberg JL.“A molecular switch for neuroprotective astrocyte reactivity” Nature. 2024, 626(7999):574-582.

  • Luo Z*, Shah S, Tanasa B, Chang KC*, Goldberg JL. "Gene regulatory roles of growth and differentiation factors in retinal development" iScience. 2024, 27(6):110100.

  • Wang S, Chen CY, Liu CC, Stavropoulos D, Rao M, Petrash JM, Chang KC* "GDF-15 Attenuates the Epithelium-Mesenchymal Transition and Alleviates TGFβ2-Induced Lens Opacity" Transl Vis Sci Technol. 2024, 13(7):2. 

Review/Perspective articles (Selective)

  • ​Chang KC, Liu PF, Chang CH, Lin YC, Chen YJ, Shu CW* “The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases” Cell Biosci. 2022,12(1):1.

  • Lo J, Mehta K, Dhillon A, Huang YK, Luo Z, Nam MH*, Aldiri I*, Chang KC* “Therapeutic strategies for glaucoma and optic neuropathies”. Molecular Aspects of Medicine. 2023, 94:101219.

  • Rao M, Chang KC* "Aldose reductase is a potential therapeutic target for neurodegeneration" Chem Biol Interact. 2024, 389:110856.

Book chapters

  • Chang KC and Petrash JM* “Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease” Advances in Experimental Medicine and Biology. 2018, Springer, 1032: 173–202. 

  • Luo Z, Nahmou M and Chang KC* “Stem Cell Therapies for Glaucoma and Optic Neuropathy” Advances in Stem Cell Biology – Recent Advances in iPSCs for Therapy. 2021, Elsevier, Volume 3, Chapter 6.

  • Rao M, Liu CC, Wang S, Chang KC* “Generating ESC-derived RGCs for cell replacement therapy” Methods in Molecular Biology – Ocular Regeneration: Methods and Protocols. 2024, Springer, 2848:187-196.

bottom of page