From Theory to Reality
The failure of adult CNS neurons to survive and regenerate their axons after injury or in neurodegenerative disease remains a major target for basic and clinical neuroscience. Here we aim to discover the potential molecules for axon regeneration in neurodegenerative diseases such as glaucoma and optic neuropathies.
Retinal cell development
The regulation of neuronal cell differentiation has interested scientists for decades. Here, we are interested in the regulatory mechanism of intrinsic and extrinsic molecules on retinal cell development.
Human stem cells and retinal organoids
Retinal ganglion cells (RGC) degenerate in glaucoma and stem cell transplant provides an opportunity for cell replacement therapy. Here we differentiate human iPSCs/ESCs into RGC-like cells (2D) and retinal organoids (3D) for cell transplantation. We also use retinal organoids as the model to study genetic eye disorders.